|
CAS RN |
: |
|
1264-72-8 |
|
EINECS RN |
: |
|
216-911-3 |
|
FORMULA |
: |
|
C53H102N16O17S |
|
MASS |
: |
|
1267.54 |
|
DESCRIPTION |
: |
|
Colistin is a polymyxin class antibiotic which has the general structure of cyclic peptide with a long hydrophobic tail. They are cationic detergent antibiotics which interfere the structure of the bacterial cell membrane and cause neuromuscular and kidney damage by acting of phospholipids. At least eleven different members of the polymyxin group have been identified and they are designated by a suffix letter. They demonstrate specific activity against gram-negative bacteria such as Proteus vulgaris, Escherichia coli, Hemophilus influenzae, Aerobacter aerogenes, Klebsiella pneumoniae and especially Pseudomonas aeruginosa. Colistin is composed of Polymyxins E1 and E2 (or Colistins A, B, and C). Colistin is is the least toxic member of the group. Colistin is used as a sulfate or as sulfomethylated form; administered orally, parenterally, and topically. |
SPECIFICATION:
|
Appearance |
white to off-white powder |
|
Identification |
Conforms |
|
Potency (Dried basis) |
19000µ/mg |
|
pH |
4.0 - 6.0 |
|
Residue on ignition |
1.0% max |
|
Loss on drying |
3.5% max |
|
Optical rotation |
-63° ~ -73° |
|
Arsenic salt |
2ppm max |
|
Heavy metals |
20ppm max |
|
Sulfate |
16.0 - 18.0% |
|
Particle size |
300mesh (98% min) |
|
Product |
CAS RN |
| Colistin | 1066-17-7 |
| Colistin sulfate | 1264-72-8 |
| polypeptin | 1404-32-6 |
| Polymyxin D | 1404-29-1 |
| Polymyxin A | 1404-24-6 |
| Polymyxin B | 1404-26-8 |
| Bacitracin1 | 1405-87-4 |
| Bacitracin zinc | 1405-89-6 |
| Polymyxin B Sulfate1 | 1405-20-5 |
| Sulfomyxin1 | 1405-52-3 |
| Polymyxin methane sulfonate | 1406-68-4 |
| Polymyxin | 1406-11-7 |
| Polymyxin B-methanesulfonic acid | 1407-09-6 |
| Polymyxin B1 | 4135-11-9 |
| Polymyxin E1, 7-L-theonine- | 6683-17-6 |
| Colistin A | 7722-44-3 |
| Cortisporin | 8024-64-4 |
| Neosporin | 8057-37-2 |
| Colistimethate sodium | 8068-28-8 |
| Subtilisin | 9014-01-1 |
| Polymyxin D1 | 10072-50-1 |
| Colistinmethanesulfonic acid | 12705-41-8 |
Colistin sodium methanesulfonate |
21362-08-3 |
| Colistin nonapeptide | 32530-94-2 |
| Neomycin-polymyxin mixture | 51273-62-2 |
|
Isododeacnoyl colistin nonapeptide hydrochloride |
51868-12-3 |
|
Isononanoyl colistin nonapeptide hydrochloride |
51868-13-4 |
| Isoheptanoyl colistin nonapeptide hydrochloride | 51868-14-5 |
| alpha-N-n-Nonanoyl colistin nonapeptide hydrochloride | 51887-93-5 |
|
n-Hexanoyl colistin nonapeptide hydrochloride |
51887-95-7 |
|
alpha-N-n-Decanoyl colistin nonapeptide hydrochloride |
51887-94-6 |
| alpha-N-n-Tetradecanoyl colistin nonapeptide hydrochloride | 51887-92-4 |
|
alpha-N-n-Dodecanoyl colistin nonapeptide hydrochloride |
51887-91-3 |
| alpha-N-n-Undecanoyl colistin nonapeptide hydrochloride | 51887-90-2 |
|
alpha-N-Octanoyl colistin nonapeptide hydrochloride |
51921-46-1 |
| Colistin hydrochloride | 52051-38-4 |
| Mix(cortisporin, mixt. with neomycin sulfate, polymyxin B sulfate ) | 52218-57-2 |
| Phenoxyacetyl colistin nonapeptide hydrochloride | 52396-34-6 |
| Colistin nonapeptide hydrochloridee | 52396-32-4 |
|
2-Phenylbutyryl colistin nonapeptide hydrochloride |
52438-36-5 |
|
beta-Naphthalenecarbonyl colistin nonapeptide hydrochloride |
52438-37-6 |
| Mix(polymyxin B, trimethoprim) | 53320-96-0 |
| Colimecycline | 58298-92-3 |
| Corti-biciron | 62253-16-1 |
| Polymyxin S1 | 63700-38-9 |
| Polymyxin T1 | 63700-39-0 |
| Polymyxin A sulfate | 63885-04-1 |
| Polymyxin F hydrochloride | 64684-15-7 |
| Polymyxin F1 | 67880-66-4 |
| Colistin heptapeptide | 75748-25-3 |
| Deacylpolymyxin B | 76014-40-9 |
| Pelargonoyl-cyclic decapeptide polymyxin B1 | 76721-93-2 |
| Polymagma C | 77554-83-7 |
| Pelargonoyl cyclic decapeptide polymyxin M1 | 77554-83-7 |
| Polymagma | 78393-44-9 |
| Pulpomixine | 78515-94-3 |
| Maxitrol | 78666-15-6 |
| Mix(neomycin, nystatin, polymyxin B sulfate, acetarsol, dimethicone) | 78891-94-8 |
| Polymyxin B nonapeptide | 86408-36-8 |
| Mix(bacitracin, polymyxin B) | 95918-76-6 |
| Mix(polymyxin B neomycin, fludrocortisone acetate, lidocaine, benzalkonium chloride) | 99401-18-0 |
| Polyspectran OS | 117733-87-6 |
| Mix(cortisporin, polymyxin B) | 118933-13-4 |
| Mix(hydrocortisone, dibucaine, neomycin sulfate, polymyxin sulfate) | 123354-95-0 |
| Polymyxin B octapeptide | 142563-39-1 |
| Polymyxin B heptapeptide | 142563-40-4 |
| Dexapolyspectran | 143305-95-7 |